Synthetic studies on pseudo-dimeric Lycopodium alkaloids: total synthesis of complanadine B.
نویسندگان
چکیده
Complanadines A and B (1 and 2, Scheme 1) are dimeric Lycopodium alkaloids from the lycodine family that possess significant activity for stimulating nerve growth factor (NGF) production in human glial cells. 2] As such, 1 and 2 are of interest as potential small-molecule leads for the treatment of neurodegenerative diseases, such as Alzheimer s disease, as well as adjuvants for the regeneration of nerve cells in, for example, spinal cord injury treatment.
منابع مشابه
Natural Product Synthesis
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عنوان ژورنال:
- Angewandte Chemie
دوره 52 6 شماره
صفحات -
تاریخ انتشار 2013